promethazine suppository stability at room temperature
Promethazine HCl Suppositories should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. help if any of these side effects or any other side effects bother you or do not go away: These are not all of the side effects that may occur. Stability at Room Temperature** FOR SPECIFIC INFORMATION, CONTACT MANUFACTURER. Patients should be told to report any involuntary muscle movements. Nonteratogenic Effects.). This method is capable of distinguishing the intact drug from its thermal and photodegradation products. A stability-indicating GLC method for the analysis of promethazine hydrochloride in polyethylene glycol delivery systems is reported. See the FDA's Safe Disposal of Medicines website ( Last updated on Jan 28, 2022. Preoperative medication: 1.1 mg/kg IM, IV, orally, or rectally once. Do not take more or less of it or take it more often than prescribed by your doctor. Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. It works by blocking the action of a certain natural substance in the body. government site. Stand up after about 15 minutes. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Promethazine HCl 50mg. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Allergic conjunctivitis due to inhalant allergens and foods. Promethazine HCl is a racemic compound; the empirical formula is C 17 H 20 N 2 SHCl and its molecular weight is 320.88. suppository. Deep IM injection is the preferred route of administration. Put suppository into the rectum with gentle pressure, pointed end first. what signs you had. Adjunctive therapy to epinephrine and other standard measures for anaphylactic reactions, after acute manifestations have been controlled, Parenteral: 6.25 to 12.5 mg IM or IV every 4 hours a day, Oral and Rectal: 12.5 to 25 mg orally or rectally 2 times a day. June 14, 2022. WebPromethazine HCL Suppository, Rectal - Uses, Side Effects, and More Common Brand(S): Phenergan, Promethegan Generic Name(S): promethazine View Free Coupon Once treatment begins, the dose should be reduced to the smallest effective amount needed to control symptoms. Promethazine Nonteratogenic Effects Promethazine is in a class of medications called phenothiazines. 1990 Apr;38(4):1027-31. doi: 10.1248/cpb.38.1027. Purpose: The aim of this review was to build upon previous literature describing the maximum duration for which refrigerated medications can tolerate room temperature excursions while maintaining stability and potency. Inform patients that this drug may cause drowsiness, and they should avoid driving or operating machinery until the full effects of the drug are seen. Promethazine is an H 2 years and older: Treatment: Oral or Rectal: 1.1 mg/kg orally or rectally every 4 to 6 hours as needed. WebStability at Room Temperature** FOR SPECIFIC INFORMATION, CONTACT MANUFACTURER Unopened vial should not be left at room temperature for a total time exceeding 12 hours prior to use. Hyperexcitability and abnormal movements have been reported in patients following a single administration of promethazine HCl. Promethazine HCl Suppositories may cause marked drowsiness or impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, such as driving a vehicle or operating machinery. Dosage must be individualized. suppository. POSTMARKETING CASES OF RESPIRATORY DEPRESSION, INCLUDING FATALITIES, HAVE BEEN REPORTED WITH USE OF PROMETHAZINE HCL SUPPOSITORIES IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE. sharing sensitive information, make sure youre on a federal Do not The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 3 0 obj Would you like email updates of new search results? If you will be giving promethazine to a child, also tell the child's doctor if the child has any of the following symptoms before he or she receives the medication: vomiting, listlessness, drowsiness, confusion, aggression, seizures, yellowing of the skin or eyes, weakness, or flu-like symptoms. This site is provided for educational and informational purposes only, in accordance with our Terms of Use, and is not intended as a substitute for the advice of a medical doctor, nurse, nurse practitioner or other qualified health professional. Call your doctor for medical Available for Android and iOS devices. Sedative doses may be given the night before surgery. Anaphylactic reactions, as adjunctive therapy to epinephrine and other standard measures, after the acute manifestations have been controlled. An official website of the United States government. Development and validation of a HPLC method for the analysis of promethazine hydrochloride in hot-melt extruded dosage forms. For children, Promethazine HCl Rectal Suppositories, 12.5 to 25 mg, twice daily, may be administered. All Rights Reserved. A&k]h/+ulm.d!*/XHvPr]SjTHc%t ?($uL Db~4;22bt`gE[6Pi*8G:#k:V`BQS=X9R2N$ARz ]x~#RVY2ZdVX lr+baz|To+-$`>*>c 7o&. Allergy The average dose is 25 mg taken before retiring; however, 12.5 mg may be taken before meals and on retiring, if necessary. Promethazine HCl in 12.5- to 25-mg doses for children and 50-mg doses for adults the night before surgery relieves apprehension and produces a quiet sleep. Promethazine is also used to relax and sedate patients before and after surgery, during labor, and at other times. The site is secure. An official website of the United States government. The syrup version of promethazine should be in a light-protected bottle with the lid tightly closed at all times. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Tell your doctor or pharmacist about all the medications your child is taking, especially barbiturates such as phenobarbital (Luminal), medications for anxiety, narcotic medications for pain, sedatives, sleeping pills, and tranquilizers. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain. If you have any questions about this medicine (promethazine suppositories), please talk Prairie View Elementary Staff Directory,
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promethazine suppository stability at room temperature